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Report CopyRight/DMCA Form For : Second Year B Pharmacy Semester Iii 2 3 1 T Physical
Polymorphism Definition Different shape of polymorphs Example and its application. to pharmacy Mention Detection techniques Glass transition temperature. Solution of Non electrolytes and Electrolytes, Properties and types of solutions ideal and real solutions Raoult s law and it s. deviations boiling point diagram fractional steam distillation Colligative properties. 04 relative lowering of vapor pressure elevation of boiling point depression of freezing 12. point and osmotic pressure problems involving molecular weight determinations. Solution of electrolytes equivalent and specific conductance Kohlrauschs law. conductometric titrations Colligative properties of electrolytes. Solubility and Distribution Phenomenon, Solute solvent interactions Solubility of Gases in liquids liquid in liquids and solids in. liquids factors affecting solubility solubility of weak electrolytes influence of pH. solvents solubility parameter and combined effect of pH and Solvents Distribution. phenomenon Nernst distribution law and its limitations Effect of ionic dissociation and. association applications in Pharmacy BCS classification. 2 3 1 P PHYSICAL PHARMACEUTICS I Practical,3 hrs week. 1 Determination of Critical solution temperature of Phenol water system. 2 Determination of effect of addition of electrolyte on CST of phenol water system. 3 Construction of ternary phase diagram for three component system toluene acetone water. 4 Construction of ternary phase diagram for three component system oil water surfactant. 5 Determination of solubility of substance at different temperatures. 6 Determination of solubility of benzoic acid in different solvents. 7 Determination of effect of co solvents on solubility of benzoic acid in water. 8 Determination of molecular weight by Rast s camphor method. 9 Determination of cell constant by conductometry, 10 Determination of unknown concentration by conductometric titration. 11 Verification of Ostwald s dilution law by conductometry. 12 Determination of partition coefficient of iodine. 13 Determination of partition coefficient of benzoic acid between water and benzene. 14 Determination of effect of pH on partition coefficient. 15 Estimation of saturation solubility of given drug in water. Recommended Books, 1 Martins Physical Pharmacy and Pharmaceutical Sciences 5 Ed Patrick J Sinka Lippincott. Williams and Wilkins, 2 Essentials of Physical Chemistry by B S Bahl G D Tuli Golden Jubilee Ed S Chand and. 3 Essentials of Physical Chemistry and Pharmacy H J Arnikar S S Kadam K N Gujar Orient. Longman Pvt Ltd India, 4 Textbook of Physical Pharmacy Vol II 3 Ed K L Kapoor McMillan India Ltd. 5 Principles of Physical Chemistry 4 Ed Samuel H Marlton Carl F Frultoon Oxford and IBH. publishing Co Pvt Ltd New Delhi, 6 Physical Pharmacy by Dr U B Hadkar NiraliPrakashan 8 Ed Mumbai. 7 Essentials of Physical Pharmaceutics by C V S Subramanyam 2 Ed Vallabh Prakashan New. 8 Textbook of Physical Pharmaceutics by C V S Subramanyam 2 Ed Vallabh Prakashan New Delhi. 9 Theory and Practice of Industrial Pharmacy by H A Liebermann Leon Lachman and J B Schwartz. 10 Physical Pharmacy by Martin Swarbrick and Cammarata Indian Edition Varghese Publishing. House Mumbai, 11 Handbook of Practical Physical Pharmacy and Physical Pharmaceutics by U B Hadkar. NiraliPrakashan 4 Ed 2007 Pune, 12 Practical Physical Pharmacy by H N More and A A Hajare Career Publication 1 Ed 2007 Nashik. 13 Practical Physical Pharmacy by Gaud and Gupta NiraliPrakashan. 14 Essentials of Physical Pharmacy by Madan and Tuli S Chand Company New Delhi. 15 Martin s Physical Pharmacy and Pharmaceutical Sciences 5 Ed by Patric J Sinka Lippincott. Williams and Wilkins 2007, 16 Essentials of Physical Chemistry and Pharmacy H J Arnikar S S Kadam K N Gujar Orient. Longman Pvt Ltd India,17 Practical Physical Pharmacy Gurtoo and Kapoor. 2 3 2 T PHARMACEUTICAL MICROBIOLOGY IMMUNOLOGY Theory. 3 Hrs Week, Learning objectives On successful completion of following theory topics laboratory experiments. learner should be able to,A Knowledge, 1 define microbiology classify microbes into various categories. 2 aware about historical developments and contributions of scientists in the field of microbiology. 3 know the recent advances in microbiology, 4 compare and contrast the various structural features biology characteristics of microbes. 5 know the modes of reproduction in bacteria growth characteristics requirements. 6 describe isolation counting methods of microorganisms. 7 explain the mechanism of tumour formation,8 illustrate use of microorganism in pharmacy. 9 identify the causes and basis of microbial spoilage. 10 know the sources types of microbial contamination. 11 explain an importance of microbial limit tests preservative efficacy test standardization processes. 12 state mechanism of action and effectiveness of various sterilization processes. 13 know the Sterility testing as per I P and its importance. 14 classify disinfectants be able to illustrate mechanism of action its evaluation. 15 focus on various basic aspects of immunology, 16 illustrate types of immunity basic aspects like antigen antibody and their various their various. 17 know the vaccines its types and preparation methods. 18 know the basics behind various reactions of antigen and antibody as well as hypersensitivity. 19 describe vaccine manufacturing process, 1 explain the principle construction and working of various instruments and perform their operations. 2 handle microscope for observation of microbes, 3 learn how to prepare and sterilize nutrient broth nutrient agar slants stabs and plates. 4 adopt the skills required for maintaining strictly aseptic condition handling inoculating loop its. sterilization and inoculation procedure, 5 isolate microorganism by streak plate technique count them by pour plate technique. 6 observe motility of bacteria by hanging drop technique. 7 execute morphology bacteria by simple staining negative staining gram staining. 8 do sterility testing of WFI by direct inoculation method. 9 determine minimum inhibitory concentration by broth dilution. 10 do Antibiotic Assay of any antibiotic,Name of the topic and contents Hrs. Introduction to Microbiology, Scope and applications to pharmaceuticals Whittaker s five kingdom concept. Classification of microbes into bacteria rickettsia actinomycetes fungi protozoa algae. and viruses and their significance related to pharmacy Historical developments. contributions of Anton van Leeuwenhoek Louis Pasteur Robert Koch and Paul Ehrlich. Size shape structure cell wall capsules spores flagella Reproduction binary fission. Growth growth curve Culture media Counting methods Preservation of microbial. cultures Significance of Prebiotics and Probiotics. Yeasts and moulds, 3 Introduction and applications of Saccharomyces cerevisiae Candida albicans and 01. Penicillium, 4 Introduction general properties structure of viruses Human viruses multiplication 03. and cultivation Structure Human Immunodeficiency virus. Microbial Limit tests, 5 Viable count Identification of specific microorganism as per IP 02. Sterilization, 6 Introduction to concept of sterilization Different methods dry heat moist heat 03. gaseous radiation and filtration,Preservation and Disinfection. 7 Chemical classification of different disinfectants with a example Phenol coefficient 03. test RW test,Fundamentals of Immunology, Microbial virulence exotoxins endotoxins Antigens Types of Immunity Defense. mechanisms of host specific and nonspecific Mechanism of CMI and HMI. Antibodies Classification,Antigen Antibody reactions. Characteristics of Antigen Antibody reaction Basics of Precipitation Agglutination. Slide and Tube Introduction to complement fixation test immunofluorescence tests. Radio Immunoassay and ELISA,Vaccines and sera, 10 Classification of vaccines General production of Vaccines and sera and their quality 05. 2 3 2 P PHARMACEUTICAL MICROBIOLOGY IMMUNOLOGY Practical. 3 Hrs Week, 1 To study the principle and working of laboratory equipments autoclave hot air oven colony. counter incubator, 2 Microscopy different parts of compound microscope resolving power magnification power. numerical aperture and working distance, 3 Preparation and sterilization of nutrient broth nutrient agar slants stabs and plates. 4 To study different techniques of Inoculation of cultures and aseptic techniques. 5 Isolation of microorganism by streak plate technique. 6 Total Viable Count TVC by pour plate technique, 7 Observation of motility of bacteria by hanging drop technique. 8 To study morphology bacteria by simple staining, 9 To study morphology bacteria by negative staining. 10 To study morphology bacteria by Gram staining, 11 Sterility testing of WFI by direct inoculation method. 12 MIC minimum inhibitory concentration determination by broth dilution. 13 Antibiotic Assay of any one antibiotic as per IP. Preservative Efficacy Test as per IP, can be included in Third year B Pharmacy or Final Year B Pharmacy. Study of microbial limits of any one raw material, to be included in Third year B Pharmacy as excipient testing. Recommended Books, 1 Anathnarayan R and Panikar C K J 2000 Textbook of Microbiology 8 Ed Orient Longman. 2 Aulton M E Pharmaceutics The Science of Dosage Form Design Churchill Livingstone 1998. 3 Baird R M et al eds Handbook of Microbiological Quality Control Pharmaceutical and. Medical Devices Taylor and Francis Inc London 2000. 4 Carter S J Copper and Gunn s Tutorial Pharmacy CBS Publishers and Distributors Delhi 1996. 5 Collee J G et al Mackie and McCartney Practical Medical Microbiology Fourteenth Edition. Churchill Livingstone Publications New York 1996, 6 Hugo W B and Russell A D Pharmaceutical Microbiology 6 Ed Blackwell Science 1998. 7 Kokare C R Pharmaceutical Microbiology Principles and Applications 6 Ed Nirali Prakashan. Pune India 2008, 8 Indian Pharmacopoeia Govt of India Ministry of Health and Family Welfare 1996 2007. 9 Pelczar M J et al Microbiology 5 Ed McGraw Hill New York 1986. 10 Rawlins E A eds Bentley s Textbook of Pharmaceutics 8 Ed Bailliere Tindall London 1992. 11 Akers M J Parenteral Quality Control 2 Ed Marcel Dekker Inc New York 1994. 12 Brooks G F Butel J S Morse S A Jawetz Metrics Adel bergs Medical Microbiology 21 Ed. Appleton Lange Publication United State of America 1989. 13 Maloy S R Cronan J E Microbial Genetics 2 Ed Narosa Publishing House New Delhi 2006. 14 Ingraham J L Ingraham C A Introduction to Microbiology 2 Ed Thomson Brooks Cole U S. 15 Wiley M Sherwood L M Woolverton C J Prescott Harley Klein s Microbiology 7 Ed. McGraw Hill International Edition 2008, 16 Frobisher M HinsDill R D Crabtrea K T Good Heart C R Fundamentals of Microbiology. 9 Ed Saunders Company Japan 1974, 17 Casida L E Industrial Microbiology 7 Ed New Age International Publication 2007. 18 Richard A Goldsby Thomas J Kindt Kuby Immunology 5th W H Freeman and company 2003. 2 3 3 T PHARMACEUTICAL BIOCHEMISTRY Theory,3 Hrs week. Learning objectives, 0n completion of following theory topics and laboratory experiments learner should able to. A Knowledge,1 explain the scope of Biochemistry in pharmacy. 2 understand role of biochemical processes cell metabolism. 3 clarify the enzyme structures their functions mechanism for enzymatic activity and applications. of enzymes, 4 draw the general metabolism process of proteins lipids carbohydrates. 5 understand basics like chemistry function classification biological importance qualitative tests. applications of various biomolecules e g proteins carbohydrates and lipids etc. 6 clarify the fundamentals of metabolism process steps involved in metabolism of carbohydrates. lipids protein and nucleic acid, 7 explain types their structures biochemical functions importance of fat soluble and water. soluble vitamins, 1 detect and identify proteins amino acids and carbohydrates by various qualitative as well as. quantitative tests, 2 separate identify and characterize proteins from various samples like egg milk etc and. understand principle behind the technique, 3 handle and operate gel chromatography UV spectrophotometer colorimeter flame photometer. and various instruments used in clinical biochemistry laboratory. 4 isolate of starch from potato and understand techniques as well as mechanism involved. 5 estimate quantity of ascorbic acid in a given sample. 6 demonstrate action of salivary amylase on starch. 7 separate proteins by SDS PAGE,Name of the topic and contents Hrs. Introduction to Biochemistry Scope of the subject in Pharmaceutical Sciences. Biochemical reactions Highlights of Prokaryotic and eukaryotic cell metabolism. Enzymes Introduction Classification Co enzymes Co factor active sites. Mechanism of enzyme actions Michaelis Menten equation Double reciprocal. plot Factors Affecting Enzyme Activity Enzyme Inhibition Reversible. irreversible Allosteric Applications of enzymes,Biomolecules. i Amino acids Introduction Classification Essential and non essential amino. acids Physicochemical properties Colour reactions Structure Peptide bond. 3 end group analysis Edman s and Sanger s method and medicinally 12. important amino acids, ii Proteins Introduction Functional classification of Helix sheet structure. Tertiary Quaternary structure Globular IgG and Haemoglobin and Fibrous. protein Keratin and Collagen, iii Carbohydrates Definition Classification Functions and biological role of. glucose fructose galactose ribose lactose maltose sucrose starch. glycogen hyaluronic acid and heparin, iv Lipids Definition Classification Functions Types of Lipids and their. biological role, v Nucleic acids Structure biochemical functions replication transcription. translation and genetic code of Eukaryotic cell,Metabolism Structures not mandatory. Electron transport chain Oxidative phosphorylation and correlation of metabolic. i Carbohydrate metabolism Glycolysis Citric acid cycle and its Amphibolic. nature Gluconeogenesis including Cori s cycle Glycogenesis. Glycogenolysis Pentose Phosphate pathway Metabolism of Galactose. ii Lipid metabolism Metabolism of Triglycerides Beta Oxidation of fatty. acids formation and utilization of ketone bodies and cholesterol. iii Protein metabolism Transamination oxidative and non oxidative. deamination of amino acids urea formation Biosynthesis of glycine and. iv Nucleic Acids metabolism Synthesis and breakdown of purines. pyrimidines, Vitamins Structure and biochemical function of fat soluble and water soluble. 2 3 3 P PHARMACEUTICAL BIOCHEMISTRY Practical,3 Hrs Week. 1 Detection and identification of proteins amino acids and carbohydrates. Minimum 9 experiments,2 Isolation of milk casein,3 Isolation of Starch from Potato. 4 Estimation of Ascorbic acid Vitamin C,5 To study action of salivary amylase on Starch. 6 Separation of Proteins by SDS PAGE,Recommended Books. 1 Lehninger s Principles of Biochemistry by Albert Lehninger 4 Ed Palgrave Macmillon. 2 Biochemistry by Lubert Stryer W H Freeman Company New York. 3 Harper s Illustrated Biochemistry by R K Murray D K Granner 27 Ed McGraw Hill. 4 An Introduction to Practical Biochemistry by David Plummer 3 Ed Tata McGraw Hill Edition. 5 Fundamentals of Biochemistry by Dr A C Deb New central book agency P Ltd Kolkata. 6 Varley s Practical Clinical Biochemistry by Harold Varley 6 Ed CBS Publishers New Delhi. 7 Laboratory Medical Technology by Prafulla Godkar. 8 Biochemistry by U Satyanarayana U Chakrapani 3 Ed Books Allied P Ltd. 9 Viva Practical Biochemistry by A C Deb 3 Ed New Central Book Agency P Ltd. 2 3 4 T PHARMACEUTICAL ORGANIC CHEMISTRY III Theory. 3 hrs Week, Learning objectives On successful completion of following theory topics laboratory. experiments learner should be able to,A Knowledge, 1 understand relevance of stereochemistry its significance in Pharmaceutical Sciences. 2 clarify Isomerism apply that knowledge in understanding the structure property. relationship, 3 explain the stereochemical aspects of the organic compounds. 4 clarify mechanism and applications of rearrangement of electron deficient electron rich. 5 comprehend explain basic concepts in pericyclic reactions. 6 explain the chemistry of amino acids and underlying concepts like isoelectric point. 7 explain the synthesis and reaction of Polycyclic Compounds. 1 make correct use of various equipments practice safety measures in Pharmaceutical. Organic Chemistry laboratory, 2 understand the chromatographic techniques in organic chemistry. 3 explain the principle and procedure involved column chromatographic separation. techniques and TLC, 4 explain significance of qualitative analysis of organic compounds synthesis of. derivatives, 5 explain and understand the principle behind various qualitative tests and analyze the. given unknown binary organic compounds having different functional groups. 6 explain synthesis recrystallisation filtration and precipitation techniques of organic. compounds along with reaction mechanism,Name of the topic and contents Hrs. Stereochemistry, Significance of stereochemistry in biological activity. Stereoisomerism Geometrical isomerism E Z nomenclature optical. isomerism chirality Fischer representation R S nomenclatures. Diastereomerism Resolution of Racemic modification Newman and. Sawhorse representation Conformational isomerism conformational. isomerism in ethane and n butane conformations of cyclohexane monoalkyl. and dialkyl cyclohexanes conformation in decalin,Molecular Rearrangement Reactions. Rearrangement of electron deficient systems migration to oxygen nitrogen. and carbon Mechanism and stereochemistry of Baeyer Villiger oxidation and. Dakin oxidations Wagner Meerwein rearrangements Pinacol Pinacolone. rearrangement Beckmann Curtius Lossen Hofmann and Schmidt. rearrangements Rearrangements of electron rich system inclusive of Stevens. Sommlet Favorskii Neber and Benzilic acid rearrangement Rearrangement. to aromatic nucleus including mechanism of Fries Claisen rearrangement. Pericyclic Reactions Electrocyclic Cycloaddition and Sigmatropic reactions. Cope rearrangement, Chemistry of amino acids Classification and structures of natural amino. 3 acids Iso electric point General methods of preparation of amino acids 5. Peptide bonds,Polycyclic Compounds, Synthesis and reaction of naphthalene phenanthrene and anthracene. 2 3 4 P PHARMACEUTICAL ORGANIC CHEMISTRY III Practical. 3 hrs week, 1 Laboratory techniques Column chromatographic separation techniques and TLC. Demonstration, 2 Separation and qualitative analysis of binary mixtures Solid Solid Any 7. 3 Organic Synthesis by rearrangements in point 2 of theory syllabus Any 5 for example. benzilic acid rearrangement pinacol pinacolone rearrangement Beckmann. rearrangement Hofmann reaction Fries rearrangement etc. 4 Demonstration of Stereomodels,Recommended Books, 1 Stereochemistry of Carbon Compounds by E L Eliel 32 reprint 2005 Tata McGraw Hill. Publishing Co Ltd New Delhi, 2 Stereochemistry of Organic Compound Principles and Applications by Nasipuri Revised. Edition New Age International Publishers, 3 Advanced Organic Chemistry by E S Gould 4 Ed Wiley Eastern Edition. 4 Principles of Organic Synthesis by Norman 3 Ed Nelson Thorns Publication. 5 Organic Chemistry by Morrison Boyd 7 Ed Pearson Education. 6 Organic Chemistry by Fieser Fieser Vol I X 1 Ed Asia Publishing House. 7 Quantitative organic Analysis by Siggsa Honna 4 Ed A Wiley Interscience. Publication John Wiley Sons, 8 Combinatorial Chemistry Principles and techniques Arpad Furka published in electronic. form by Arpad Furka Budapest 2007, 9 Vogel s Textbook of Practical Organic Chemistry by A I Vogel 5 Ed Pearson. 10 Handbook of Organic Analysis Qualitative and Quantitative by H T Clarke 1 Ed. Arnold Heinemann, 11 Experimental Pharmaceutical Organic Chemistry A Benchtop manual K S Jain P B. Miniyar and T S Chitre Career Publication second edition 2006. 12 Indian Pharmacopoeia 1996 Published by ministry of health and family welfare. 13 Stereochemistry Conformation and Mechanism by P S Kalsi 7 Ed 2008 New Age. International Publishers New Delhi, 14 Advanced General Organic Chemistry A Modern Approach by Sachin Kumar Ghosh. 3 Ed 2009 New Central Book Agency P Ltd, 15 Organic Chemistry by Jonathan Clayden Nick Greeves Stuart Warren 2 Ed 2012. Oxford University press, 16 Advanced Organic Chemistry Reactions Mechanisms Structures by Jerry March. Wiley India P Ltd New Delhi, 17 Organic Chemistry Volume 2 Stereochemistry and the chemistry of natural products by. I L Finar 5 Ed 2007 Pearson Education Ltd,2 3 5 T PHARMACOLOGY I Theory. 3 hrs week, Learning objective On successful completion of following theory topics learner should be able to. 1 know basics of pharmacology like history scope general principles. 2 define drug and illustrate on types of drugs including their use. 3 compare contrast various routes of administration with advantages and disadvantages. 4 associate an information regarding new drug discovery and development process. 5 aware about basics of pharmacokinetic and pharmacodynamic parameters. 6 classify receptors and correlate them to various proteins present in the body. 7 know the principles site mechanisms and factors modifying drug action. 8 understand the concept of adverse drug reactions and drug toxicity so that it can get minimize. 9 describe synthesis storage release physiological pathophysiological role of autacoids and. pharmacology of their antagonists, 10 give examples of rational drug treatment during pregnancy and lactation pediatric patients in. geriatric patients,Name of the topic and contents Hrs. Basics of Pharmacology, Definitions history scope general principles of pharmacology nature sources of. drug drug nomenclature type of drugs essential drug medicine concept National Drug. Policy rational use of medicine,Routes of Drug Administration. Classification merits and demerits of individual route factors governing choice of route. 3 New drug Discovery and Development Process 02,Pharmacokinetics. Biological membranes Structure and function of cell membrane Transportation of drug. across cell membrane Factor governing transportation of drug. Absorption Bioavailability of Drug Definitions Factors affecting absorption and. bioavailability of drug, Distribution Definitions volume of distribution Factors affecting drug distribution. 4 Physiological barriers Plasma protein binding of drug 15. Metabolism Definitions organs and enzymes involved in drug metabolism Enzyme. induction and inhibition first pass metabolism of drug Phases of drug metabolism. Factors affecting drug metabolism, Excretion Definitions route of excretion Factors affecting excretion of drug. Basic concepts of Clinical Pharmacokinetics Bioavailability Bioequivalence Half. life of drug Clearance Therapeutic drug monitoring TDM. Pharmacodynamics, Principles of drug action Site and mechanisms of drug action factors modifying drug. 5 action structure activity relationship SAR Drug receptors classification and families of 09. receptors regulation of receptors Drug receptor interaction Dose response curve and. Therapeutic Index,Principles of Therapeutics, 6 Individualization of drug therapy Combined effects of drugs Adverse drug reactions 05. ADR Types intensity of ADR Reporting of ADRs Drug Interactions Drug Toxicity. Types and general principles of management of drug toxicity. Autacoids Synthesis storage release physiological pathophysiological role of. following autacoids and pharmacology of their antagonists. i Histamine and its antagonists,ii 5 HT and its antagonists. iii Kinins Prostaglandins Leukotrienes Platelet activating factor Angiotensin and their. antagonists,Clinical Pharmacology, 8 Rational drug treatment during pregnancy and lactation pediatric patients in geriatric 05. Recommended Books, 1 Goodman and Gillman The Pharmacological Basis of Therapeutics McGraw Hill Medical. Publishing Division NewYork, 2 Rang H P and Dale M M Pharmacology Churchill Livingstone Elsevier. 3 Katzung B G Basic and Clinical Pharmacology Lange Medical Publications California. 4 Bowman W C and Rand M J Textbook of Pharmacology Blackwell Scientific Publications Oxford. 5 Pradhan S N Maickel R P and Dutta S N Pharmacology in Medicine Principles and Practice S P. Press International Inc Maryland, 6 Craig C R and Stitzel R E Modern Pharmacology with clinical application Lippincott Williams. 7 Melman K I and Morelli H F Clinical Pharmacology Basic Principles in Therapeutics Macmillan. Press New York, 8 Laurence D R and Bennett P N Clinical Pharmacology Churchill Livingstone Edinburgh. 9 Bevan J A and Thompson J H Essentials of Pharmacology Harper and Row Publishers. Philadelphia, 10 Drill V A Pharmacology in Medicine McGraw Hill Co New York. 11 Grollman A Pharmacology Therapeutics Lea Fabiger Philadelphia. 12 Avery G S Drug Treatment Adiss Press Sydney, 13 Das M M and Dutta S K Ghosh s Modern Concepts on Pharmacology Therapeutics Hilton. Co Calcutta, 14 Barar F S K Essentials of Pharmacotherapeutics S Chand Co New Delhi. 15 Krantz and Carr Pharmacology Principles of Medical Practice Williams Wilkins Co Baltimore. 16 Satoskar R S and Bhandarkar S D Pharmacology Pharmacotherapeutics Popular Prakashan. 17 Vyawahare N S and Vora S A Textbook of General Pharmacology Nirali Prakashan Pune. 18 Pharmacopoeia of India 1985 Controller of publication Delhi. 19 Tripathi K D Essentials of Medical Pharmacology Jaypee Brothers Medical Publishers New. 20 Vyawahare N S Pawar A T and Takawale R V Pharmacology I Tech Max Publications Pune. 2 3 6 T PHARMACOGNOSY PHYTOCHEMISTRY I Theory,03 Hrs Week. Learning objectives on successful completion of theory and laboratory experiments learner. should be able to,A Knowledge, 1 explain meaning significance of Pharmacognostic parameters Pharmacognostic study of. crude drugs, 2 comprehend explain underlying reason of evolutionary significance of secondary metabolites. production in plants other organisms deduce their significance as medicinal molecules. Learner should be able to explain evolution of Phytochemistry to current phase. 3 comprehend explain primary metabolites comprehensively from source to their. Pharmaceutical industrial applications In relation with primary metabolites learner should be. able to define classify explain source name draw chemical structures identify from the. structure organize the biosynthetic sequence describe methods of extraction underlying. rationale of qualitative quantitative analysis explain general processes of preparation of semi. synthetic products explain their properties, 4 define classify explain source name draw chemical structures identify from the structure. organize the biosynthetic sequence and describe methods of extraction underlying rationale. of qualitative quantitative analysis of glycosides tannin compounds of plant origin. 1 able to prepare permanent slides explain the significance of reference material such as. herbarium specimen permanent slides etc in plant authentication. 2 demonstrate skill of plant material sectioning staining mounting focusing. 3 decide on staining reagents required for specific part of plant. 4 identify the parts of plants from its morphological microscopical features by applying. experimental theoretical knowledge of morphology anatomy obtained in theory classes. 5 draw morphological microscopical diagrams able to label component parts. 6 able to conduct extractions isolations explain significance of use of various chemicals. physical conditions, 7 able to identify unorganized crude drugs samples of powders of organized unorganized. crude drugs using morphological chemical physical microscopical characteristics. 8 able to handle various equipments as per SOPs such as spectrophotometer Tintometer simple. compound digital microscope Abbe s Refractometer Melting point apparatus judge the. quality of material, 9 explain significance of how laboratory experiments are linked with social needs. 10 able to judge the quality of crude drugs by different means explain the significance of same in. commerce industry,Name of the topic and contents Hrs. Plant metabolites, 1 Primary secondary metabolites Meaning types their functions in plant 3. Comparative account of primary secondary metabolism Role of secondary. metabolites in plants Rationale behind use of secondary metabolites as medicinal. compounds Overview of historical contribution in development of phytochemistry. Pharmacognostic scheme for study of crude drugs Meaning component. significance of individual Pharmacognostic parameter. Primary metabolites of Pharmaceutical industrial utility. General consideration Definition classification occurrences properties. nomenclature chemistry including general biogenesis qualitative quantitative. analysis pharmaceutical industrial applications of carbohydrates lipids. proteins their derived products,A Carbohydrates, a Systematic Pharmacognostic study of Agar Guar gum Acacia Isabagol. Sterculia Tragacanth Okra mucilage, b Source extraction properties uses of Starch pectin inulin chitosan. cyclodextrins, a Systematic Pharmacognostic study of Castor oil Linseed oil Neem oil. Hydnocarpus oil Codliver oil Shark liver oil Rice Bran oil Cocoa butter. Kokum butter Wool fat Bees wax, b Source extraction properties uses of Lecithin Polyunsaturated fatty acids. Carotenoids, C Proteins enzymes Source method of preparation properties uses of. Thaumatin Papain Bromelin Streptokinase gelatin, D Natural fibers Source method of preparation properties applications of. Cotton Wool Silk Jute,2 3 6 P PHARMACOGNOSY PHYTOCHEMISTRY I Practical. 03 Hrs Week,1 Preparation of permanent slides, 2 Study of morphology microscopy powdered characteristics drugs mentioned in theory. syllabus Min 3 Exp, 3 Qualitative analysis of unorganized crude drugs fibers drugs mentioned in theory syllabus. 4 Determination of swelling index of mucilage pectin containing crude drugs. 5 Extraction isolation of mucilage Isapgol seeds Okra fruits. 6 Extraction isolation of pectin from citrus peels. 7 Characterization of starches by microscopical technique. 8 Determination of specific gravity refractive index colour acid value saponification value. unsaponifiable matters of fixed oils determination of melting point of fat Min 4 Exp. 9 Estimation of tannins by Spectrophotometer hide powder assay. 10 Systematic approach for identification of powdered crude drugs. Recommended Books, 1 Evans W C Trease G E Trease and Evan s Pharmacognosy W B Saunders 2002 16th. Ed ISBN 10 0702029335, 2 Francisco A Macias Jose L G Galindo Juan C G Galindo Evolution and current status of. ecological Phytochemistry Phytochemistry 68 2007 2917 2936. http www dzumenvis nic in Microbes 20and 20Plants 20Growth pdf Evolution 20and 2. 0current 20status 20of 20ecological pdf, 3 Jean Bruneton Caroline K Hatton Pharmacognosy phytochemistry medicinal plants. Lavoisier 1999 ISBN 1898298637, 4 Kokate C K Gokhale S B and Purohit A P Textbook of Pharmacognosy Nirali Prakashan. Pune 2008 ISBN 8185790094, 5 Mukherjee Pulok K Quality Control of Herbal Drugs An Approach to Evaluation of. Botanicals Business Horizons 2002 ISBN 8190078844, 6 Quality control methods for medicinal plant materials World Health Organization Geneva. 1998 ISBN 9241545100, 7 Rangari V D Pharmacognosy Phytochemistry Vol I Career Pub Nashik 2009 ISBN. 978 81 88739 45 5, 8 Rangari V D Pharmacognosy Phytochemistry Vol II Career Pub Nashik 2009 ISBN. 978 81 88739 65 3, 9 Roy Lester Whistler James N BeMiller Industrial gums polysaccharides and their. derivatives Academic Press 1993 ISBN 0127462538, 10 Seigler David S Plant Secondary Metabolism Kluwer Academic Publishers Dordrecht the. Netherlands 1995 ISBN 0 412 01981 7, 11 Severian Dumitriu Polysaccharides Structural Diversity and Functional Versatility CRC. Press 2004 ISBN 0824754808, 12 Thomas Hartmann From waste products to ecochemicals Fifty years research of plant. secondary metabolism Phytochemistry Volume 68 Issues 22 24 2007. http www sciencedirect com science article pii S0031942207005730. 13 Wallis T E Textbook of Pharmacognosy CBS Publisher Distributors 1985 ISBN 81 239. 14 Wink M Functions and Biotechnology of Plant Secondary Metabolites Annual plant. reviews volume 39 2nded Blackwell Publishing Ltd 2010 ISBN 978 1 4051 8528 8. 15 Brain K R Turner T D The Practical Evaluation of Phytopharmaceuticals Wright. Scientechnica Bristol 1975, 16 Khandelwal K R Practical Pharmacognosy Pragati Books Pvt Ltd ISBN 8185790302. 17 Kokate C K Practical Pharmacognosy Vallabh Prakashan 1993. 18 Wallis T E Practical Pharmacognosy J A Churchill Ltd London 1953. 19 Jeffrey B Harborne Phytochemical Methods A Guide to Modern Techniques of Plant. Analysis Springer 1998 ISBN 0412572702 9780412572708. 20 Manual of methods of analysis of foods Oils Fats. http www fssai gov in Portals 0 Pdf 15Manuals OILS 20AND 20FATS pdf.
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Elly Blue Bikenomics (2013) Blogs, articles, and other book chapters (These will be available on Moodle) Podcasts and video clips Bicycle logs: Each week students will keep track of their bicycling activity. These entries will include mileage and possibly challenges, physical and cognitive experiences, and inspiration among other short reflections. At the end of the semester, students will ...
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