Hormones And The Heart In Health And Disease-Books Pdf

HORMONES AND THE HEART IN HEALTH AND DISEASE
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CONTEMPORARY ENDOCRINOLOGY,P Michael Conn SERIES EDITOR. 22 Gene Engineering in Endocrinology edited by MARGARET A SHUPNIK 2000. 21 Hormones and the Heart in Health and Disease edited by LEONARD SHARE 1999. 20 Endocrinology ofAging edited by JOHN E MORLEY AND LUCRETIA VAN DEN BERG 2000. 19 Human Growth Hormone Research and Clinical Practice edited by Roy G SMITH. AND MICHAEL 0 THORNER 1999, 18 Menopause Endocrinology and Management edited by DAVID B SEIFER AND. ELIZABETH A KENNARD 1999, 17 The IGF System Molecular Biology Physiology and Clinical Applications . edited by RON G ROSENFELD AND CHARLES T ROBERTS JR 1999. 16 Neurosteroids A New Regulatory Function in the Nervous System edited by. ETIENNE EMILE BAULIEU MICHAEL SCHUMACHER AND PAUL ROBEL 1999. 15 Autoimmune Endocrinopathies edited by ROBERT VOLPE 1999. 14 Hormone Resistance Syndromes edited by J LARRY JAMESON 1999. 13 Hormone Replacement Therapy edited by A WAYNE MEIKLE 1999. 12 Insulin Resistance The Metabolic Syndrome X edited by GERALD M REAVEN AND. AMI LAWS 1999, 11 Endocrinology of Breast Cancer edited by ANDREA MANNI 1999. 10 Molecular and Cellular Pediatric Endocrinology edited by. STUART HANDWERGER 1999, 9 The Endocrinology of Pregnancy edited by FULLER W BAZER 1998.
8 Gastrointestinal Endocrinology edited by GEORGE H GREELEY JR 1999. 7 Clinical Management of Diabetic Neuropathy edited by ARISTIDIS VEVES 1998. 6 G Proteins Receptors and Disease edited by ALLEN M SPIEGEL 1998. 5 Natriuretic Peptides in Health and Disease edited by WILLIS K SAMSON. AND ELLIS R LEVIN 1997, 4 Endocrinology of Critical Disease edited by K PATRICK OBER 1997. 3 Diseases of the Pituitary Diagnosis and Treatment edited by. MARGARET E WIERMAN 1997, 2 Diseases of the Thyroid edited by LEWIS E BRAVERMAN 1997. 1 Endocrinology of the Vasculature edited by JAMES R SOWERS 1996. HORMONES AND THE,HFART IN HFALTH,AND DISFASE,Edited by. LEONARD SHARE,University ofTennessee Memphis TN, SPRINGER SCIENCE BUSINESS. MEDIA LLC, 1999 Springer Science Business Media New York.
Originally published by Humana Press Inc in 1999, Softcover reprint of the hardcover 1st edition 1999. For additional copies pricing for bulk purchases and or in formation about other Humana titles . contact Humana at the above address or at any of the following numbers Tel 973 256 1699 . Fax 973 256 8341 E mail humana humanapr com or visit our Website at http humanapress com. Ali rights reserved No part ofthis book may be reproduced stored in a retrieval system or transmitted in any form or. by any means electronic mechanical photocopying microfilm ing recording or otherwise without written permission. from the Publisher , AII articles comments opinions conclusions or recommendations are those ofthe author s and do not necessarily reflect. the views ofthe publisher , This publication is printed on acid free paper Gi . ANSI Z39 48 1984 American National Standards Institute . Permanence ofPaper for Printed Library Materials ,Cover design by Patricia F Cleary . Photocopy Authorization Policy , Authorization to photocopy items for interna orpersonal use or the interna orpersonal use of specific clients is granted.
by Springer Science Business Media LLC provided that the base fee of US 10 00 per copy plus US 00 25 per page . is paid directly to, the Copyright Clearance Center at 222 Rosewood Drive Danvers MA 01923 For those organizations that have been. granted a photocopy license from the CCC a separate system ofpayment bas been arranged and is acceptable to Springer. Science Business Media LLC The fee code for users of the Transactional Reporting Service is 0 89603 726 6 99. 10 00 00 25 ,10 9 8 7 6 5 4 3 2 1, Hormones and the heart in health and disease edited by Leonard Share. p cm Contemporary endocrinology 20 , Includes index . ISBN 978 1 4757 5420 9 ISBN 978 1 59259 708 6 eBook . DOI 10 1007 978 1 59259 708 6, 1 Heart Physiology 2 Autocrine mechanisms 3 Atrial natriuretic peptides Physiological effect . 4 Endothelins Physiological effect 5 Hormones Physiological effect 6 Catecholamines Physiological. effect 1 Share Leonard II Series Contemporary endocrinology Totowa NJ 20 . DNLM 1 Heart physiology 2 Peptides physiology 3 Hormones physiology . WG 202E561 1999 , QP111 4E53 1999, 612 1 73 ic21, DNLM DLC.
for Library of Congress 99 10459, CIP, PREFACE, The maintenance of arterial blood pressure and the distribution of blood flow to the. various organs of the body depends on the control of the pumping action of the heart and. of the resistance of the vascular beds in the individual organs in accordance with their. metabolic needs These controls are achieved through the integrated actions of circulat . ing hormones humoral factors that are synthesized and released in the heart and blood. vessels and the autonomic nervous system The heart however is not only the target for. the direct and indirect actions of a number of hormones and humoral factors it is also an. endocrine organ in the traditional sense synthesizing and secreting into the circulation. chemical factors that act at distant sites In this treatise Hormones and the Heart in Health. and Disease we interpret endocrinology broadly and consider traditional hormones as. well as autocoids that are secreted by the heart or that act on it In this overview the. relevant chapters are indicated in parentheses , The discovery of atrial natriuretic peptide ANP atrial natriuretic factor ANF in the. 1980s indicated that the heart does indeed function as an endocrine organ in the classic. sense ANP Chapter I is synthesized in the heart and secreted into the circulation for. actions on the kidney where it is a potent natriuretic agent and on the vasculature where. it causes vasodilation ANP can also affect myocardial contractility . The heart among several other organs can also synthesize the recently discovered. peptide humoral factors adrenomedullin Chapter 2 and urocortin Chapter 3 . Adrenomedullin synthesis is stimulated by volume and pressure overload and may be. released into the circulation under these circumstances Adrenomedullin is a potent. vasodilator that can also affect myocardial function Urocortin is a newly discovered. member of the ACTH family of peptides The demonstration that it causes potent and. long lasting vasodilation and an increase in myocardial contractility suggests that it may. be a particularly important cardiovascular hormone . The heart is the direct target for several circulating hormones Of particular interest in. heart failure is the renin angiotensin aldosterone system Chapter 4 Elevated circulat . ing angiotensin II as well as angiotensin II produced locally in the heart can adversely. affect myocardial function This is of particular importance in the failing heart Elevated. plasma concentrations of aldosterone a mineralocorticoid as well as glucocorticoids . can also exert negative effects on the heart via structural remodeling and electrolyte. disturbances Chapter 5 The heart can also synthesize corticosteroids and these may. exhibit autocrine and paracrine actions , The autonomic nervous system plays a major role in determining the pumping action. of the heart Chapter 6 The sympathetic nervous system and catecholamines exert. positive inotropic and chronotropic actions on the heart These effects are opposed by. acetylcholine released from vagal nerve endings and neuropeptide Y released from sym . pathetic nerve endings Understanding these interactions is key to understanding the. participation of the heart in cardiovascular regulation . Vasopressin is not only the antidiuretic hormone it is also a potent vasoconstrictor It. has also been demonstrated that vasopressin at physiologically relevant plasma concen . trations can decrease heart rate and cardiac output Chapter 7 and that these actions. occur at vasopressin levels that are too low to increase arterial blood pressure These. v, vi Preface, effects of vasopressin largely result from its central actions on the sympathetic nervous. system and on baroreflex sensitivity , Insulin Chapter 8 contributes to both the acute and chronic regulation ofthe mechani .
cal function of the heart The importance ofthe long term actions of insulin on the heart. is indicated by the cardiomyopathy that occurs in diabetes mellitus Much is known about. the cellular basis for this action ofinsulin and about its actions on myocardial metabolism . The components of the kallikrein kinin system necessary for the generation of brady . kinin are present in the heart and vascular tissue Chapter 9 Kinins probably act prima . rily as paracrine agents local hormones exerting important cardioprotective actions. through the release of various autocoids The cardioprotective action of angiotensin . converting enzyme ACE inhibitors may be due in part to inhibition of the enzymes that. degrade kinins The well known autocoids endothelin Chapter 10 nitric oxide Chap . ter 11 and eicosanoids Chapter 12 are also synthesized in the heart and modulate. cardiac performance under physiological and pathophysiological conditions Endothelin. is a potent constrictor of the coronary vasculature and can affect myocardial contractility. and hypertrophy Nitric oxide on the other hand is a potent vasodilator It can also affect. myocardial contractility and can influence myocardial metabolism The synthesis of. eicosanoids in the heart can be stimulated by activating both the adrenergic and cholin . ergic nervous systems and by several circulating and locally generated humoral factors . The eicosanoids exert important modulatory effects on the heart in physiological and. pathophysiological circumstances , It is well known that the incidence of heart disease is lower in premenopausal women. than in men The possibility that estrogen exerts a cardioprotective action is of consid . erable interest physiologically and clinically Chapter 13 This cardioprotective effect. of estrogen may result in part from its actions on coronary artery endothelium and smooth. muscle and on lipid metabolism On the other hand there is evidence that testosterone in. men is a risk factor for coronary artery disease Chapter 14 This may be related to the. observation that testosterone treatment in men can reduce the plasma concentration of. high density lipoprotein cholesterol , It is the intent of this treatise to survey and evaluate the hormonal and autocrine factors. that modulate cardiac performance in health and disease . Dr JayM Sullivan the author of Chapter 13 EstrogenandtheHeart died on February. 22 1999 at the age of 62 He was Chief of the Division of Cardiovascular Diseases of. the Department of Medicine at the University ofTennessee Memphis and he was known. for his work on salt sensitivity in hypertension and the role of estrogen in protecting. against cardiovascular disease He will be missed greatly as a physician and scholar and . for those of us who knew him as a colleague and friend . Leonard Share PHD, CONTENTS, Preface v, Contributors ix. 1 Natriuretic Peptides and the Heart 1, David G Gardner Branka Kovacic Milivojevic Faquan Liang . and Songcang Chen, 2 Adrenomedullin and the Heart 21.
Willis K Samson, 3 Cardiac and Vascular Actions ofUrocortin 39. David G Parkes and Clive N May, 4 The Renin Angiotensin System and the Heart 53. Haralambos Gavras and Irene Gavras, 5 Adrenocortical Hormones and the Heart A Steroidogenic. Endocrine Organ as Well as Target Organ 69, Celso E Gomez Sanchez. 6 Catecholamines and the Heart 81, Matthew N Levy.
7 Vasopressin and the Heart 103, Vernon S Bishop and Max G Sanderford. 8 Insulin and the Heart 115, Roger W Brownsey Brian Rodrigues Subodh Verma . and John H McNeill, 9 Kinins in the Heart 137, Oscar A Carretero. 10 Endothelin and the Heart 159, David P Brooks and Eliot H Ohlstein. 11 Nitric Oxide and the Heart 175, Robert D Bernstein Fabio A Recchia Gabor Kaley .
and Thomas H Hintze, 12 Contribution of Eicosanoids in the Heart 195. Kafait U Malik, 13 Estrogen and the Heart 219, Jay M Sullivan. 14 Androgen and Estrogen Effects on Plasma Lipids in Men 235. Carrie J Bagatell and William J Bremner, Index 253. Vll, CONTRIBUTORS, CARRIE J BAGATELL MD Puget Sound Veterans Medical Center Seattle WA. ROBERT D BERNSTEIN BA Department of Physiology New York Medical College . Valhalla NY, VERNON S BISHOP PHD Department of Physiology The University of Texas Health.
Science Center San Antonio TX, WILLIAM J BREMNER MD PHD Department ofMedicine Seattle VA Medical Center . Seattle WA, DAVID P BROOKS PHD Department of Renal Pharmacology SmithKline Beecham . King of Prussia PA, ROGER W BROWNSEY PHD Department of Biochemistry and Molecular Biology . The University ofBritish Columbia Vancouver BC Canada. OSCAR A CARRETERO MD Hypertension and Vascular Research Division . Henry Ford Hospital Detroit MI, SONGCANG CHEN MD Metabolic Research Unit University of California . San Francisco CA, DAVID G GARDNER MD Metabolic Research Unit University of California .
San Francisco CA, HARALAMBOS GAVRAS MD Hypertension and Atherosclerosis Section . Boston University School ofMedicine Boston MA, IRENE GAVRAS MD Hypertension and Atherosclerosis Section Boston University. CONTEMPORARY ENDOCRINOLOGY P Michael Conn SERIES EDITOR 22 Gene Engineering in Endocrinology edited by MARGARET A SHUPNIK 2000 21 Hormones and the Heart in Health Disease edited by LEONARD SHARE 1999 20 Endocrinology of Aging edited by JOHN E MORLEY AND LUCRETIA VAN DEN BERG 2000 19

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